Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles
€ 172,90
Informação do Produto
| ISBN | 9783030540791 |
|---|---|
| Autores | Hyung Yoon |
| Editora | Springer Nature Switzerland AG |
| Formato | Capa mole |
| Número de páginas | 212 |
| Data de Publicação | 03/09/2021 |
| Preço (iva excl.) | € 163,11 |
| Imposto | € 9,79 |
| Preço (iva inc.) | € 172,90 |
| Disponibilidade | 1 unidade em armazém externo |
Descrição do Produto
This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon–carbon bonds in high atom- and step-economy. In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, andhighlights its synthetic utility. Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C–H activation and p-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions.