Caveolins and Caveolae
€ 172,90
Informação do Produto
| ISBN | 9781461412212 |
|---|---|
| Editora | Springer-Verlag New York Inc. |
| Formato | Capa dura |
| Número de páginas | 184 |
| Data de Publicação | 30/01/2012 |
| Preço (iva excl.) | € 163,11 |
| Imposto | € 9,79 |
| Preço (iva inc.) | € 172,90 |
| Disponibilidade | 1 unidade em armazém externo |
Descrição do Produto
Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.