Inhibitors of Protein–Protein Interactions
€ 252,90
Informação do Produto
| ISBN | 9781788015691 |
|---|---|
| Editora | Royal Society of Chemistry |
| Formato | Capa dura |
| Número de páginas | 356 |
| Peso (kg) | 0,698 |
| Data de Publicação | 07/12/2020 |
| Preço (iva excl.) | € 238,58 |
| Imposto | € 14,32 |
| Preço (iva inc.) | € 252,90 |
| Disponibilidade | 2 unidades em armazém externo |
Descrição do Produto
Protein–protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.