Cytochrome P450
€ 198,90
Informação do Produto
| ISBN | 9781071615416 |
|---|---|
| Editora | Springer-Verlag New York Inc. |
| Formato | Capa dura |
| Número de páginas | 379 |
| Data de Publicação | 10/07/2021 |
| Preço (iva excl.) | € 187,64 |
| Imposto | € 11,26 |
| Preço (iva inc.) | € 198,90 |
| Disponibilidade | 1 unidade em armazém externo |
Descrição do Produto
This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading.